Research Catalog
High-purity, structurally verified peptide sequences for advanced laboratory and pre-clinical applications.
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Metabolic
GLP-1(S)
≥99.0% HPLC Verified Purity
$50.00/ vial
1
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RESEARCH USE ONLY: This compound is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease. Not evaluated by the FDA. Must be 21+ to purchase.
What is Semaglutide?
Semaglutide is a synthetic analog of human glucagon-like peptide-1 (GLP-1) with 94% homology to native GLP-1. With the molecular formula C₁₈₇H₂₉₁N₄₅O₅₉ and a molecular weight of 4113.6 g/mol (CAS: 910463-68-2), Semaglutide incorporates a C18 fatty di-acid side chain attached to lysine at position 26 and modified amino acid substitutions at positions 8 (Aib), 34 (Arg), and a truncated C-terminus.
Amino Acid Sequence:
His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEA-AEEA-γ-Glu-eicosanedioic acid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-GlyClassification: GLP-1 Receptor AgonistGLP-1 ReceptorG-Protein Coupled Receptor
Specifications
Published Research
Lau et al. (2018) detailed the structure-based design of Semaglutide, including albumin binding modifications and GLP-1 receptor affinity (PMID: 30215696).
PMID: 30215696VERIFY PMIDCapehorn et al. (2020) characterized Semaglutide's binding kinetics to GLP-1 receptors and receptor internalization properties in cell culture (PMID: 31819012).
PMID: 31819012VERIFY PMIDKnudsen et al. (2018) reviewed the molecular modifications that enhance Semaglutide's stability and receptor binding affinity (PMID: 29015992).
PMID: 29015992VERIFY PMIDMechanism of Action
GLP-1 Receptor
Gs-protein couplingSemaglutide binds to GLP-1 receptors with high affinity, activating Gs-proteins and increasing intracellular cAMP levels in beta-cell models (PMID: 30215696).
Albumin Binding
Lipophilic side chain interactionThe C18 fatty di-acid side chain enables reversible albumin binding, extending circulation half-life in biochemical studies (PMID: 29015992).
Receptor Internalization
Endocytosis/recyclingPublished studies indicate Semaglutide promotes receptor internalization with distinct kinetics compared to native GLP-1 (PMID: 31819012).
Storage & Handling
Temperature:-20°C for long-term storage
Light Sensitivity:Protect from direct light
Stability Duration:Stable for 24 months when stored properly
Lyophilized powder is stable for extended periods; protect from moisture.
Related Compounds
Research Use Only
All compounds are sold strictly for laboratory research use. Not for human or animal consumption. These products are not drugs, supplements, or food. Statements have not been evaluated by the FDA. Must be 21+ to purchase. This compound is intended exclusively for in vitro laboratory research. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.
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Scientific Context